KINGSTON, R.I., June 28, 2018 \u2014 A $3.3 million grant from the National Institutes of Health will support a 溏心vlog免费B站 neuroscientist\u2019s research to identify early-stage biomarkers for a brain disease often found to coexist with Alzheimer\u2019s disease.<\/p>\n
The five-year grant was awarded to William Van Nostrand, Hermann Professor of Neuroscience at 溏心vlog免费B站\u2019s George & Anne Ryan Institute for Neuroscience. The funding will help fill a critical research niche in early detection of cerebral amyloid angiopathy, a disease in which\u00a0amyloid deposits form in small and medium blood vessels in the central nervous system, contributing to dementia and brain hemorrhages. Although the disease is common in the elderly, it often isn\u2019t diagnosed until its late stages, when bleeds can be detected by brain imaging.<\/p>\n
\u201cEarly and accurate diagnosis of this condition has remained elusive,\u201d said Van Nostrand. \u201cThere is a need for biomarkers for early stages of disease prior to the presence of lesions detected by neuroimaging. The purpose of this project is to fill this void by developing and validating robust biological fluid markers for CAA.\u201d<\/p>\n
The project, which begins in July, will be conducted in collaboration\u00a0with Professor Marcel Verbeek at Radboud University Medical Center in Nijmegen, Netherlands, based on previous work by the Verbeek and Van Nostrand labs\u00a0that identified potential cerebral amyloid angiopathy biomarkers in brain tissue.\u00a0A biological fluid marker not only could potentially provide an earlier, more accurate diagnosis of the disease, but could also help guide treatment options, particularly in therapies where the disease represents a heightened risk of hemorrhage.<\/p>\n
Van Nostrand arrived at the Ryan Institute in the fall of 2017 from Stony Brook, bringing with him $4.1 million in grant funding. He is noted for being the first researcher to purify and characterize amyloid precursor protein, the progenitor of the amyloid-beta protein that forms hallmark plaques in Alzheimer\u2019s disease. \u201cOur goal is ultimately to identify mechanisms of disease that could be targets for new treatments,\u201d he said.<\/p>\n
Founded in 2013, the Ryan Institute for Neuroscience is focused on investigating factors in neurodegenerative disease that have been under-explored, including inflammation, the immune system, and the role of blood vessels in the development and progression of disease.<\/p>\n","protected":false},"excerpt":{"rendered":"
KINGSTON, R.I., June 28, 2018 \u2014 A $3.3 million grant from the National Institutes of Health will support a 溏心vlog免费B站 neuroscientist\u2019s research to identify early-stage biomarkers for a brain disease often found to coexist with Alzheimer\u2019s disease. The five-year grant was awarded to William Van Nostrand, Hermann Professor of Neuroscience at 溏心vlog免费B站\u2019s […]<\/p>\n","protected":false},"author":2,"featured_media":74094,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-74093","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts\/74093","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/comments?post=74093"}],"version-history":[{"count":0,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts\/74093\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/media\/74094"}],"wp:attachment":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/media?parent=74093"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/categories?post=74093"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/tags?post=74093"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}