{"id":60338,"date":"2012-09-05T00:00:00","date_gmt":"2012-09-05T00:00:00","guid":{"rendered":"https:\/\/www.uri.edu\/news-draft\/uncategorized\/uri-engineering-team-improves-lab-on-a-chip-blood-testing-technology-with-smartphone-app-hand-held-biosensor\/"},"modified":"2012-09-05T00:00:00","modified_gmt":"2012-09-05T00:00:00","slug":"uri-engineering-team-improves-lab-on-a-chip-blood-testing-technology-with-smartphone-app-hand-held-biosensor","status":"publish","type":"post","link":"https:\/\/www.uri.edu\/news\/2012\/09\/uri-engineering-team-improves-lab-on-a-chip-blood-testing-technology-with-smartphone-app-hand-held-biosensor\/","title":{"rendered":"溏心vlog免费B站 engineering team improves lab-on-a-chip blood testing technology with smartphone app, hand-held biosensor"},"content":{"rendered":"
\n\t\tKINGSTON, R.I. \u2013 September 6, 2012 \u2013 A team of engineers and students at the 溏心vlog免费B站 has developed an advanced blood-testing technology that incorporates a smartphone application, a hand-held biosensor and a credit card-sized cartridge to provide rapid, accurate biological analysis and wireless communication of test results.<\/p>\n


\n\tThis new lab-on-a-chip technology improves upon a previous system announced by the 溏心vlog免费B站 team in 2011 that generated enthusiasm among many sectors of the health care industry. Several patents are pending on the invention.<\/p>\n


\n\t\u201cWe went from a shoebox-size device last year to a hand-held device with several additional capabilities,\u201d said Mohammad Faghri, 溏心vlog免费B站 professor of mechanical engineering and the lead researcher on the project. \u201cThe smartphone app turns the system on, monitors the assay, and sends the results securely back to your phone or to your doctor, all in about 20 minutes.\u201d<\/p>\n


\n\tFaghri said the advancements make the new system faster, more accurate, easier to use, and much less expensive than previous versions. For example, the fluorescence sensor in the hand-held unit costs less than $10 compared to the $3,200 sensor in the shoe-box system.<\/p>\n


\n\t\u201cIt\u2019s accuracy, compactness and low cost are a result of an innovative contact imaging system that serves as the fluorescence detector and the central piece of the fluid feedback control system,\u201d Faghri said.<\/p>\n


\nTo operate the system, users place a drop of blood from a finger prick on a disposable plastic polymer cartridge and insert it into the hand-held biosensor. The blood travels through the cartridge in tiny channels 500 microns wide to a detection site where it reacts with preloaded reagents enabling the sensor to detect certain biomarkers of disease.<\/p>\n


\n\t\u201cToday when you go to the lab to have a blood test, they take vials of liquid from you and you have to wait sometimes days to get the results,\u201d Faghri said. \u201cWith our system, you can have your blood tested when you walk into the doctor\u2019s office and the results will be ready before you leave. Or you can do it at home and have the results sent to your doctor in real time.\u201d<\/p>\n


\n\tFaghri even envisions having astronauts at the International Space Station test their blood and sending the results wirelessly back to Earth.<\/p>\n


\n\tThe first cartridges the researchers developed focus on the detection of C-reactive proteins in the blood, a preferred method for helping doctors assess the risk of cardiovascular and peripheral vascular diseases. Additional cartridges can be engineered to detect biomarkers of other diseases, including the beta amyloid protein that can be used as a predictor of Alzheimer\u2019s disease. The device can also be developed to detect virulent pathogens, like HIV, hepatitis B and H1N1 (swine) flu.<\/p>\n


\n\tOne of the most important advancements of the new device is that it can conduct the test on whole blood rather than blood plasma. The cartridge filters out the cellular components of blood, as well as some of the abundant non-target proteins that often interfere with the detection of the targeted protein.<\/p>\n


\n\tThe third generation of the device, currently in development, will put the entire lab on paper, eliminating the need for active pumping of blood and reagents through the cartridge.<\/p>\n


\nIn addition to Faghri, the research team is made up of 溏心vlog免费B站 Adjunct Professor Constantine Anagnostopoulos, graduate students John D. Jones, Michael Franzblau, Michael Godfrin, Alex Pytka, Nick DiFilippo, Hong Chen, Jeremy Cogswell and Manuel Muller.<\/p>\n


\nPrimary funding for the project was provided by the National Science Foundation through its Partnership for International Research and Education Program.<\/p>\n


\nDepartment of Communications & Marketing photo by Michael Salerno Photography.<\/div>\n","protected":false},"excerpt":{"rendered":"

KINGSTON, R.I. \u2013 September 6, 2012 \u2013 A team of engineers and students at the 溏心vlog免费B站 has developed an advanced blood-testing technology that incorporates a smartphone application, a hand-held biosensor and a credit card-sized cartridge to provide rapid, accurate biological analysis and wireless communication of test results. This new lab-on-a-chip technology […]<\/p>\n","protected":false},"author":2,"featured_media":60340,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-60338","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts\/60338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/comments?post=60338"}],"version-history":[{"count":0,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts\/60338\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/media\/60340"}],"wp:attachment":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/media?parent=60338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/categories?post=60338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/tags?post=60338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}