{"id":102350,"date":"2025-05-20T18:11:56","date_gmt":"2025-05-20T18:11:56","guid":{"rendered":"https:\/\/www.uri.edu\/news\/?p=102350"},"modified":"2025-05-22T00:06:03","modified_gmt":"2025-05-22T00:06:03","slug":"uri-college-of-pharmacy-researcher-studies-link-between-stroke-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.uri.edu\/news\/2025\/05\/uri-college-of-pharmacy-researcher-studies-link-between-stroke-and-alzheimers-disease\/","title":{"rendered":"溏心vlog免费B站 College of Pharmacy researcher studies link between stroke and Alzheimer\u2019s Disease"},"content":{"rendered":"\n<p>KINGSTON, R.I. \u2014 May 20, 2025 \u2014 Why does stroke increase the risk of Alzheimer\u2019s disease and other dementias? A 溏心vlog免费B站 <a href=\"https:\/\/web.uri.edu\/pharmacy\/\">College of Pharmacy<\/a> researcher is investigating the link between stroke and dementias in a study funded by a $413,000 grant from the National Institutes of Health. Assistant Professor Claudia Fallini hopes her research will lead to a better understanding of the mechanisms that contribute to Alzheimer\u2019s disease, as well as to improved stroke outcomes.<\/p>\n\n\n\n<p>Ischemic stroke, caused by lack of blood supply to the brain, kills and damages brain cells, often triggering harmful neuroinflammation or other pathological changes that have been associated with Alzheimer\u2019s disease and dementia. However, it remains unclear how and why stroke triggers these changes, and exactly how such changes increase the risk of developing Alzheimer\u2019s dementia.<\/p>\n\n\n\n<p>\u201cThere is a knowledge gap around which cellular pathways cause or contribute to dementia after a stroke,\u201d says Fallini, who has a joint appointment to the <a href=\"https:\/\/ryaninstitute.uri.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">George &amp; Anne Ryan Institute for Neuroscience<\/a>. \u201cIt is important to bridge this gap in order to understand how stroke affects your risk for developing Alzheimer\u2019s disease and find potential ways to mitigate that risk.\u201d<\/p>\n\n\n\n<p>One potential pathway of interest includes the actin cytoskeleton, which plays a critical role in various cellular functions and has long been a focus of Fallini\u2019s research. \u201cIschemic stroke has been shown to induce drastic changes in the actin cytoskeleton,\u201d says Fallini, who also holds an appointment in the <a href=\"https:\/\/web.uri.edu\/cels\/\">College of the Environment and Life Sciences<\/a>. \u201cOne of our questions is to look at how some of the changes we see in this pathway after a stroke could make surviving brain cells more vulnerable to age-related stressors or other factors linked to Alzheimer\u2019s disease.\u201d<\/p>\n\n\n\n<p>Fallini hopes the project will be a step toward developing potential new therapies.<\/p>\n\n\n\n<p>\u201cWe hope that our work will provide new pieces of the puzzle toward a better understanding of the fundamental mechanisms that lead to cognitive decline and dementia,\u201d Fallini said. \u201cIf we can identify what\u2019s happening in the brain after a stroke that causes or contributes to dementia and Alzheimer\u2019s disease, we have a better chance to intervene.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>KINGSTON, R.I. \u2014 May 20, 2025 \u2014 Why does stroke increase the risk of Alzheimer\u2019s disease and other dementias? A 溏心vlog免费B站 College of Pharmacy researcher is investigating the link between stroke and dementias in a study funded by a $413,000 grant from the National Institutes of Health. Assistant Professor Claudia Fallini hopes [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":102351,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[41,5,1905],"class_list":["post-102350","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-archives","tag-college-of-pharmacy","tag-college-of-the-environment-and-life-sciences","tag-research"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts\/102350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/comments?post=102350"}],"version-history":[{"count":1,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts\/102350\/revisions"}],"predecessor-version":[{"id":102352,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/posts\/102350\/revisions\/102352"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/media\/102351"}],"wp:attachment":[{"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/media?parent=102350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/categories?post=102350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uri.edu\/news\/wp-json\/wp\/v2\/tags?post=102350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}